UOT201715668 - Services to Generate and Maintain Mutant Mouse Lines

The purpose of this Advance Contract Award Notice (ACAN) is to signal the University’s intention to award a contract for the above-noted goods and/or services to the pre-selected supplier:

The Centre for Phenogenomics
25 Order Street
Toronto, Ontario
M5T 3H7

Prior to awarding this contract, the University is providing other potential Suppliers with the opportunity to demonstrate that they are capable of satisfying the requirements as per this ACAN, by submitting a Statement of Capabilities during the 15 calendar day posting period.

Our research focuses on mechanisms underlying the regulation of gene expression and how these mechanisms are disrupted in human diseases. Most of our research is directed at understanding how alternative splicing is regulated and integrated with other layers of gene expression to control fundamental biological processes. In this project, we wish to generate mice deficient in a specific protein that is predicted to cause to neurological changes in the brain of the affected mice. The goal is to identify these changes in neural structure and function including any possible changes in mouse behaviour.